2nd New Mexico Workshop on Computational Cell Biology:

Microscopy, Membrane Biology and Modeling for Biosignaling Research

Welcome Page

Cell behavior is regulated though the integrated activities of multiple complex signal transduction pathways. Hundreds of different proteins are implicated in intracellular and intercellular signaling cascades. The efficiency, specificity, and duration of these pathways is modulated by the chemical modification and dynamic translocation of proteins, the nature and remodeling of interacting lipids, by rapid and localized changes in cytoplasmic pH, Ca2+ levels and a by a myriad of other factors. Given this complexity, it is not surprising that dysregulated signal transduction is critically involved in many human diseases, especially cancer.

Over the past several decades, the need to apply multiple tools and technologies has driven a fundamental shift in biosignaling research from a focus on single investigator studies to a focus on teams and programs. The next fundamental shift, recognized by new funding initiatives at NIH, NSF and DoE, is the broadening of these teams to cross the boundaries between the traditional medical, science and engineering disciplines and departments. The mix of scientists in New Mexico is ideal to meet the challenge of improving human health through multidisciplinary biosignaling research.

The goal of this workshop is to bring together New Mexico's biomedical scientists with our strong communities of materials scientists, chemists, physicists, mathematicians and computer scientists to share and expand our expertise: in the development of new probes and instruments for electron and fluorescence microscopy; in the application of these and complementary tools to image, measure and analyze cell signaling networks; and in the integration of new knowledge into predictive models that reveal the structure and dynamics of multiscale biological systems.

 The workshop's sponsors include:

- The New Mexico Consortium for Bioresearch, New Mexico's consortium of universities, national laboratories ands research institutes dedicated to creating a healthier and safer world for present and future generations through innovative research and education
- The UNM/ SNL Center for the Spatiotemporal Modeling of Cell Signaling , New Mexico's NIGMS-funded Center of Excellence in Complex Biomedical Systems Research at the University of New Mexico and Sandia National Laboratories
- Sandia National Laboratories , Helping our nation secure a peaceful and free world through technology
- The UNM Cancer Research and Treatment Center, New Mexico's NCI-funded Center for Cancer Prevention, Treatment and Research
- The Center for Advanced Studies (CAS), a Center of the UNM College of Arts and Sciences with the primary mission of initiating, supporting, and expanding opportunities for interdisciplinary research and education in the five science departments in the College.

These sponsors hope for a strong turnout of scientists and students from all of New Mexico's universities, national laboratories and research institutes for an informal meeting in a lovely location. We will count the meeting an initial success by the new friendships and interdisciplinary collaborations that emerge from our two days together. The long term goal is improved human health resulting from exciting and productive collaborations between individuals and institutions in New Mexico. We look forward to your participation!

Program

The second workshop on Computational Cell Biology brings together New Mexico's bioresearch community to explore cell signaling and trafficking networks through innovations in microscopy, membrane biology and computational modeling. Participants include cell and molecular biologists, chemists, physicists, mathematicians, computer scientists and engineers.

Scientific Committee:
 

• Janet Oliver, Pathology and CRTC, UNM
• Grant Heffelfinger, Materials and Process Center, Sandia National Laboratories
• Stanly Steinberg, Mathematics and Statistics, UNM
• Stephanie Forrest, Computer Science, UNM
• Eric Prossnitz, Cell Biology and CRTC, UNM
• Bridget Wilson, Pathology and CRTC, UNM
• Angela Wandinger-Ness, Pathology and CRTC, UNM
• Antonio Redondo, Theoretical Division, LANL

Program Schedule:

Wednesday, January 14: 4:00 - 6:00 pm Advisory Board Meeting of the Advisory Board of the University of New Mexico/SNL Center of Excellence in Complex  Biomedical Systems Research (Spatiotemporal Modeling Center). By Invitation Only 6:30 - 8:00 pm Advisory Board Dinner By Invitation Only   Thursday, January 15: 7:45 - 9:00 am Continental Breakfast 9:00 - 9:30 am Welcome and Introductions Moderator: Grant Heffelfinger, STMC, SNL and NM Bioconsortium Opening remarks: Senior leaders, University of New Mexico, SNL 9:30 - 12:30 pm Session 1: Imaging Signaling and Trafficking Networks in Cells 9:30 - 9:35 am: Janet Oliver, University of New Mexico Introduction to the session and moderator 9:35 - 10:10 am: Angela Wandinger-Ness, University of New Mexico Temporal and spatial control of Rab GTPases, lipid kinases and phosphatases: Importance in endocytosis 10:15 - 10:50 am: Dusanka Deretic, University of New Mexico Regulation of rhodopsin trafficking by protein-lipid interactions: involvement of PIP2, rab and  rho GTPases and their regulatory proteins 10:50 - 11:10 am: Break 11:15 - 11:50 am: Eric Prossnitz, University of New Mexico Imaging of GPCR signalling and trafficking 11:55 - 12:30 pm: Bill Shuttleworth, University of New Mexico Comparison of intracellular Ca2+ signals evoked by  physiological and degenerative stimulation of central neurons 12:15 - 1:15 pm Lunch 1:25 - 4:50 pm Session 2 : New Probes and Microscopes for Biosignaling Research 1:25 - 1:30 pm: Jun Liu, SNL Introduction to the session and moderator 1:30 - 2:05 pm: Timothy Boyle, SNL Novel functionalized nanoprobes for use as biological imaging agents 2:10 - 2:45 pm: David Haaland, SNL Improved microarray analysis and multifluorophore imaging with hyperspectral image analysis 2:50 - 3:25 pm: Alan Burns, SNL Domain structure in model membranes investigated by simultaneous atomic force microscopy and fluorescence imaging 3:30 - 4:00 pm: Break 4:00 - 4:10 pm: Jim Thomas, University of New Mexico Introduction of Professor Watt W. Webb 4:10 - 5:00 pm: Keynote Speaker - Watt W. Webb Microscopic to Nanoscopic: Assaying the molecular dynamics of life 5:15 - 7:00 pm Posters and no-host bar 7:00 pm Dinner Buffet Friday, January 16: 7:30 - 9:00 am Continental Breakfast 9:00 - 9:30 am Introductions Moderator: Stanly Steinberg, University of New Mexico and STMC Speakers: Mac Hyman, LANL SIAM's vision for the math/biology interface Eric Loker, University of New Mexico Overview of the COBRE in Theoretical and Evolutionary Immunology 9:30 - 12:35 pm Session 3: Imaging and Modeling Domain Organization in Biological and Artificial Membranes 9:30 - 9:35 am: Danny Rintoul, SNL Introduction to the topic and moderator 9:35 - 10:10 am: Bridget Wilson, University of New Mexico Role of membrane microdomains in IgE receptor signaling 10:15 - 10:50 am: Shawn Means, SNL Endoplasmic Reticulum Luminal Calcium Dynamics: From Geometry Reconstruction to Spatial Modeling 10:50 - 11:20 pm: Break 11:25 - 12:00 pm: Mark Stevens, SNL Simulations of membrane and membrane proteins 12:05 - 12:40 pm: Turab Lookman, LANL Modeling phase separation and curvature effects in two-component membranes 12:45 - 1:45 pm Lunch 1:50 - 5:05 pm Session 4: Computational Approaches for the Analysis of Biological Networks 1:50 - 2:00 pm: Byron Goldstein, LANL Introduction to the topic and moderator 2:00 - 2:35 pm: Jim Faeder, LANL Modeling Complex Formation in Signal Transduction: What we've learned so far. 2:40 - 3:15 pm: Alex Slepoy, SNL  ChemCell: Three dimensional stochastic simulation of bio-molecular pathways. 3:15 - 3:35 pm: Break 3:40 - 4:25 pm: Maggie Werner-Washburne, University of New Mexico Genomic Analyses of rapid responses in yeast cells, or human brains are really small 4:30 - 5:05 pm: Stephanie Forrest, University of New Mexico Approaches to network modeling 5:10 pm Conference Wrap Up

Sponsors:

• The New Mexico Consortium for Bioresearch
• The University of New Mexico(UNM)/Sandia National Laboratories (SNL) Center for the Spatiotemporal Modeling of Cell Signaling (STMC)
• Sandia National Laboratories
• The UNM Cancer Research and Treatment Center (CRTC)

The sponsors look for a strong turnout of scientists and students from all of New Mexico's universities, national laboratories and research institutions. The long-term goal is improved human health that is the result of exciting and productive collaborations. We look forward to your participation!